Not much is known about Professor Magnolia's history; other than she has been a Pokémon Professor for many years, having given Leon and Sonia there first Pokémon when they began their own journeys. Her husband died many years ago, while her daughter, Sonia's mother is said to have travelled to a distant region years ago and never returned, leading to Sonia and Magnolia's close bond. She has studied Dynamaxing for many years, and was the brain child behind the research that led Chairman Rose to invent the Dynamax Band, giving Trainers the ability to control when their Pokémon can go through the change.
Professor Magnolia first appeared in GF002 when she met Lexi. She had been studying about Dynamax and Gigantamaxing for many years, having being the brain behind the Dynamax Band. She often spoke to Lexi on the phone, scolding her for not looking after herself like a stereotypical grandmother.
In GF052, after Pokémon had begun Dynamaxing without power, she contemplated her future as a Professor as Chairman Rose had admitted she could of worked harder. In GF064, she retired her Professor title to Sonia, deciding to live out her retirement out of her home, while helping out Sonia now and again.